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9,10-SECOPREGNANE DERIVATIVE AND PHARMACEUTICAL

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专利名称:9,10-SECOPREGNANE DERIVATIVE AND

PHARMACEUTICAL

发明人:FUJIEDA, HIROKI,OTSU,

HIRONORI,YASUFUKU, SHOJI,SHIRAI,MASAAKI

申请号:EP07744608申请日:20070601公开号:EP2025667A4公开日:20120829

摘要:A main object of the invention is to provide a novel useful vitamin D derivative,which has an excellent vitamin D activity and, as compared with conventional vitamin Dderivatives, has a relatively small amount of influence on the systemic calciummetabolism. The invention includes a 9,10-secopregnane derivative of the followinggeneral formula [1] and a pharmaceutical composition containing it as active ingredient.In the general formula [1], the following partial structure between the 16-position andthe 17-position means a single bond or a double bond: Y is a single bond, an alkylene, analkenylene or phenylene; R and R are the same or different, each represents hydrogen,an alkyl or a cycloalkyl; or R and R, taken together with the adjacent carbon atom, form acycloalkyl; R is hydrogen or methyl; Z is hydrogen, hydroxy or -NRR

申请人:NIPPON SHINYAKU CO., LTD.

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