Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Triclabendazole68786-66-3HY-B0621359.66C14H9Cl3N2OS>98%Solubility:DMSO 70 mg/mL; Water <1 mg/mLMechanisms: Pathways:Cell Cycle/DNA Damage; Target:Microtubule/Tubulin Biological Activity:Triclabendazole(CGA317) is a benzimidazole, it binds to tubulin impairing intracellular transportTriclabendazole(CGA317)isabenzimidazoleitbindstotubulinimpairingintracellulartransportmechanisms and interferes with protein synthesis. Target: Microtubule/Tubulin Triclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3%and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence ofTCBZ-resistant Fasciola hepatica in sheep and cattle on this farm [1]. Triclabendazole sulphoxide(50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica,whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of thetegument covering the spines [2]. Triclabendazole is metabolized into a number of compounds, depending on the route ofadministration, plasma levels peak at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hou...References:[1]. Moll, L., et al., Resistance of Fasciola hepatica against triclabendazole in cattle and sheep inThe netherlands. Vet Parasitol, 2000. 91(1-2): p. 153-8. [2].Robinson,M.W.,etal.,Triclabendazole-resistant[2]. Robinson, M.W., et al., Triclabendazoleresistant Fasciola hepatica: betaFasciolahepatica:beta-tubulintubulin and responseandresponseto in vitro treatment with triclabendazole. Parasitology, 2002. 124(Pt 3): p. 325-38. [3]. Fairweather, I., Triclabendazole: new skills to unravel an old(ish) enigma. J Helminthol, 2005.79(3): p. 227-34. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr
