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专利名称：CDNA, GENOMIC, AND PREDICTED PROTEIN
SEQUENCES OF LEARNING-INDUCEDKINASES
发明人：Richard F. Thompson,Hiroshi Gomi,William
Sun
申请号：US10174794申请日：20020618
公开号：US20030166220A1公开日：20030904
摘要：To elucidate molecular mechanisms in learning and memory, the expression ofmRNAs in brains of rabbitsundergoing eyeblink conditioning was analyzed. Infusion of thetranscription inhibitor actinomycin D (ActD) into the cerebellar nuclei reversibly blockedlearning but not performance of the CR. Differential display PCR (DD-PCR) analysis ofcerebellar RNAs from trained and pseudo-trained rabbits identified a 207-bp band thatwas induced with learning. The fragment was used to isolate a cDNA from a &lgr;gt11rabbit brain library containing a 1698-bp open-reading frame. The genomic sequence alsohas been obtained and is reported. The deduced amino acid sequence contains theKKIAMRE motif, which is conserved among cdc2-related kinases. These results suggestthat there is a new category of cdc2-related kinases in the brain whose function may beimportant in learning and memory.
申请人：THOMPSON RICHARD F.,GOMI HIROSHI,SUN WILLIAM
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